A recent study indicates that people who stop using new GLP-1 drugs like semaglutide or tirzepatide may regain shed pounds much more quickly than those who halt traditional diet and exercise regimens.
Published data in a major medical journal points out that while obese people frequently drop substantial amounts of their body weight while using the jabs, the weight returns at an average rate of 0.8 kg per month upon discontinuation.
"Users buying such treatments must be cognizant of the danger of fast weight regain when the treatment ends," warns expert Dr. Susan Jebb.
That rate of regain implies a reversion to original weight in about one and a half years.
Analyzing Treatments
The analysis, which reviewed 37 of studies involving thousands of participants, contrasted the results of the injectable medications with older methods.
Researchers point out that individuals who shed pounds through diet and exercise typically see a more gradual creep back—approximately 0.1 kg a month—post-intervention.
The Reason for the Rapid Regain
Nutrition scientists propose the way of the injections explains the heightened weight return.
The injections mimic a body's own chemical called GLP-1, which controls appetite.
"Sustained high doses of GLP-1 levels several times higher than normal could lead to the system to produce less of its endogenous hormone, and could diminish responsiveness to its actions," explained Dr. Adam Collins, a nutrition expert.
"Withdrawal of this hormone supplement means appetite is uncontrolled, making binge eating a significant risk."
A Chronic Disease?
The NHS suggest the injections for people with obesity-related medical conditions, alongside prescribed lifestyle changes.
Many experts argue that, due to the high risk of weight regain, the treatment might need to be life-long.
This view is echoed by drug manufacturers, who state that the findings "emphasize the persistent nature of excess weight," similar to managing diseases like high blood pressure.
Patient Accounts
Individuals who have stopped the jabs describe a sudden return of cravings.
"It felt as if a trigger flipping and you become extremely hungry," said one woman.
This difficulty is worsened if users have not established permanent dietary or behavioural changes during therapy.
Widespread Use
Recent estimates suggest that a significant number of adults in the UK have tried weight-loss jabs in the last 12 months, with desire remaining high.
- Adoption is greater among females compared to men.
- The 40s and 50s demographic shows the greatest level of interest.
- Many obtain the drugs through private healthcare rather than public health services.
Ultimately, researchers emphasize that while these medications are powerful agents for shedding pounds, they are not a permanent cure and long-term success likely depends on integrated lifestyle management.
